Search results for "somatic oncogene mutations"

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Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology

2016

Somatic mutation analysis represents a useful tool in selecting personalized therapy. The aim of our study was to determine the presence of common genetic events affecting actionable oncogenes using a MassARRAY technology in patients with advanced solid tumors who were potential candidates for target-based therapies. The analysis of 238 mutations across 19 oncogenes was performed in 197 formalin-fixed paraffin-embedded samples of different tumors using the OncoCarta Panel v1.0 (Sequenom Hamburg, Germany). Of the 197 specimens, 97 (49.2%) presented at least one mutation. Forty-nine different oncogenic mutations in 16 genes were detected. Mutations in KRAS and PIK3CA were detected in 40/97 (4…

AdultMale0301 basic medicineOncologymedicine.medical_specialtyColorectal cancersomatic oncogene mutationsDNA Mutational Analysismedicine.disease_cause03 medical and health sciences0302 clinical medicineGermline mutationNeoplasmsInternal medicineHumansMedicineoncocartaPrecision MedicineGeneAgedAged 80 and overGeneticsMutationbusiness.industryHigh-Throughput Nucleotide Sequencingpersonalized medicineMiddle AgedPrecision medicinemedicine.diseaseClinical trial030104 developmental biologyOncologySpectrometry Mass Matrix-Assisted Laser Desorption-Ionization030220 oncology & carcinogenesisFemalePersonalized medicineKRASbusinessResearch PaperOncotarget

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PEPhysical Sciences and Engineering
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